Published June 17, 2004
by Springer .
Written in English
Molecular Biology Intelligence Unit
|The Physical Object|
|Number of Pages||208|
In Protein Kinase C Protocols, leading investigators from academia and industry present a comprehensive collection of classical and emerging laboratory techniques for the study of this influential protein, all optimized for successful and reproducible results. Described in step-by-step detail, these methods can be easily used to explore the Format: Hardcover. PKC causes phosphorylation of membrane-bound regulatory proteins in VSM. MARCKS (myristoylated, alanine-rich C kinase substrate), a major PKC substrate, is bound to F-actin and may function as a cross-bridge between cytoskeletal actin and the plasma membrane .Also, PKC causes phosphorylation of the inhibitory GTP-binding protein G i, facilitating the dissociation of the α i subunit from Cited by: 1. Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration. 1 Family members - Isoforms. Binding phospholipids. HGNC: rows We used ePK and aPK HMMs, and Blast/psi-Blast with divergent kinase sequences, to .
Open Library is an open, editable library catalog, building towards a web page for every book ever published. Protein kinase C by Lodewijk V. Dekker, , Springer edition, paperback Protein Kinase C ( edition) | Open Library. It gets added by a protein kinase. So protein kinase uses ATP, transfers that gamma phosphate to a protein. So now you have many proteins, more than half the proteins in our bodies exist either as a dephosphorylated molecule or as a phosphorylated molecule. ISBN: OCLC Number: Description: x, pages: illustrations ; 24 cm: Contents: Protein kinase C: history and perspective / Peter J. Parker --Molecular and catalytic properties of protein kinase C / Charles W. Mahoney and Kuo-Ping Huang --Molecular mechanism of protein kinase C regulation by lipids / Andrew F.G. Quest and Robert M. Bell --Protein kinase C. Get this from a library! Protein kinase C. [Lodewijk V Dekker;] -- Devoted entirely to Protein Kinase C, this book forms a major point of reference for those active in the field. In addition it will appeal to those with a general interest in biochemistry, cell.
Diacylglycerol binds to and activates protein kinase C (PKC). The IP3 binds to ligand-gated receptor/Ca++ channels on internal membranes, leading to an influx of calcium ions into the cytoplasm. Calcium ions bind to a calcium modulatory protein, calmodulin, which binds to and activates the calmodulin-dependent kinase (CAM-PK). Since the discovery that protein kinase C (PKC) transduces the ab- dance of signals that result in phospholipid hydrolysis, this enzyme has been at the forefront of research in signal transduction. Protein Kinase C Protocols covers fundamental methods for studying the structure, function. Gschwendt, M., Kielbassa, K., Kittstein, W., and Marks, F. () Tyrosine phosphorylation and stimulation of protein kinase C delta from porcine spleen by src in vitro. Dependence on the activated state of protein kinase C delta. FEBS Lett. , 85– PubMed CrossRef Google ScholarCited by: 7. An association between protein kinase C (PKC) signaling and T cell proliferation has been recognized for almost three decades. Over 30 years ago, it was determined that a combination of phorbol esters and elevated intracellular calcium potently induces proliferation of cells of the T cell lineage (e.g., Whitfield et al., ; Lyall et al., ; Sutherland et al., ).Cited by: